Pfizer and BioNTech coronavirus vaccine delivers promising immune response in trial

• Another coronavirus vaccine candidate has shown promising results in a Phase 1/2 trial conducted in the US.
• An mRNA experimental drug made by BioNTech, which partnered with Pfizer for the development of the drug, proved it can deliver the neutralizing antibodies that would be able to block the coronavirus and prevent infection.
• According to the data the two companies released, including the full study for the clinical trial, various doses of the test drug can elicit a better immune response than the one observed in COVID-19 survivors.

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After Inovio’s promising coronavirus vaccine results earlier this week, Pfizer and BioNTech announced similar results for an ongoing Phase 1/2 clinical trial. The two companies started the US part of the trial in early May, days after a similar test began in Germany. The scientists observed neutralizing antibodies in volunteers who received the BNT162b1 drug that were at higher levels than similar antibodies from COVID-19 survivors. The vaccine candidate encodes an optimized SARS-CoV-2 receptor binding (RBD) antigen, and the immune system creates antibodies that should be able to block the virus from binding to cells, thus preventing infection.

BNT162b1 is the most advanced of four vaccine candidates from BioNTech's BNT162 mRNA vaccine program. Each of them uses a unique combination of mRNA and target antigen, the two companies explained in a press release.

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Pfizer and BioNTech coronavirus vaccine delivers promising immune response in trial originally appeared on BGR.com on Wed, 1 Jul 2020 at 22:08:25 EDT. Please see our terms for use of feeds.

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